adoDB

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ADOdb is a database abstraction library for PHP. There is also a Python version; see the ADOdb for Python docs.

The PHP version currently supports an amazing number of databases, thanks to the wonderful ADOdb community: MySQL, PostgreSQL, Interbase, Firebird, Informix, Oracle, MS SQL, Foxpro, Access, ADO, Sybase, FrontBase, DB2, SAP DB, SQLite, Netezza, LDAP, and generic ODBC, ODBTP. The Sybase, Informix, FrontBase and PostgreSQL, Netezza, LDAP, ODBTP drivers are community contributions. Here is the complete list of drivers.

Many popular web applications such as ACID, PostNuke, Xaraya, phpWiki, Mambo, PHP GACL, TikiWiki, eGroupWare and phpLens App Server are using ADOdb as their database abstraction layer.